A forested valley with autumn foliage, a rocky cliff, and a sunset.
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Southern Illinois Vacations from $249

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top destinations in Southern Illinois

The Latest Southern Illinois Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Oct 22 - Oct 25

    The Wildwood Hotel + Flight

    Wildwood
    3 nights
    3.5 star property
    9.2/10 - Wonderful (1,674 reviews)
    "Very nice stay, enjoyed everything about it, especially the extraordinarily courteous staff"
    Reviewed July 28, 2026
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    $512
    $249
    per traveler
    found 1 day ago
    The Wildwood Hotel
  • Sep 3 - Sep 7

    Remodeled and Inviting Free EV + Flight

    Fenton
    4 nights
    2.0 star property
    10/10 - Exceptional (1 review)
    "The property was excellent, and the home was very warm and welcoming."
    Reviewed June 25, 2026
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    Save 100% on your flight
    $728
    $430
    per traveler
    found 1 day ago
    Remodeled and Inviting Free EV
  • Oct 22 - Oct 25

    The Cheshire + Flight

    Richmond Heights
    3 nights
    4.0 star property
    8.8/10 - Excellent (1,006 reviews)
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    Save 100% on your flight
    $501
    $333
    per traveler
    found 1 day ago
    The Cheshire
  • Oct 20 - Oct 24

    The Principal Hotel + Flight

    Columbia
    4 nights
    3.5 star property
    9.6/10 - Exceptional (347 reviews)
    Roundtrip Denver (DEN) - St. Louis (STL)
    DEN - STLNonstop STL - DENNonstop
    Save 100% on your flight
    $521
    $368
    per traveler
    found 1 day ago
    The Principal Hotel
  • Oct 22 - Oct 25

    Hermann Grain Bins BNB + Flight

    Hermann
    3 nights
    2.0 star property
    6.0/10 - (2 reviews)
    "It was so comfortable and uniquely and beautifully decorated! There was so many awesome areas to explore inside and outside of the Grain Bins. Food provided for breakfast was fresh and hot. There was perfectly cooked bacon, scrambled eggs and really moist corn muffins with homemade mango preservers! We were welcomed with fresh, homemade plum bread. Instructions for everything available to utilize and operate were easy to understand. I can’t wait to go back and I will tell all my friends and..."
    Reviewed May 22, 2026
    Roundtrip Dallas (DFW) - St. Louis (STL)
    DFW - STLNonstop STL - DFWNonstop
    Save 100% on your flight
    $1,104
    $782
    per traveler
    found 12 hours ago
    Hermann Grain Bins BNB

Discover the most popular places to visit in Southern Illinois

Southern Illinois Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book with confidence

Things to do near Southern Illinois

Southern Illinois offers a perfect blend of outdoor adventures and romantic escapes. Visitors can enjoy thrilling ziplines, scenic wine tastings, and extensive hiking trails that showcase the area's natural beauty. With its charming campgrounds and recreational areas, Southern Illinois is ideal for those seeking both excitement and relaxation in a picturesque setting.

Shopping

King City Square Shopping Center, located 5 miles from Southern Illinois, offers a vibrant shopping experience with a mix of entertainment and family-friendly activities. Explore various stores for unique gifts and souvenirs that capture the essence of the region.

Recreation

Experience the vibrant culture at the Benton Civic Center, where entertainment meets romance. Enjoy the serene wellness vibes of Lincoln Park, perfect for relaxation, or visit Waltonville Public Use Area for a peaceful retreat in nature, fostering rejuvenation and tranquility just a short drive away.

Adventure

The I-57 Drag Strip offers thrilling motor racing experiences, located 23 miles from Southern Illinois. Feel the adrenaline rush as cars zoom past, surrounded by a vibrant atmosphere filled with sports enthusiasts. It's an exhilarating spot for anyone looking to embrace high-speed excitement.

Nightlife

Southern Illinois boasts a vibrant nightlife with unique bars and live music venues. Check out the Hangar 9 in Carbondale for great live performances and craft brews. For a relaxed vibe, visit Pheasant Hollow Winery to enjoy local wines and scenic views while unwinding with friends.

Find the best attractions near Southern Illinois

Southern Illinois is perfect for outdoor enthusiasts and those seeking romantic getaways, offering stunning scenery and adventure. Explore its beautiful lakes, national and state parks, and modern colleges and universities. The area's attractions cater to travelers looking for unforgettable outdoor experiences amidst breathtaking landscapes.

  • Jefferson County Fairgrounds: Located 3 miles from Southern Illinois, the Jefferson County Fairgrounds offers a lively atmosphere perfect for family outings. Experience local culture through seasonal fairs, exhibitions, and events, with plenty of outdoor space for relaxing and enjoying the festivities.
  • Rend Lake: A scenic 13 miles from Southern Illinois, Rend Lake is a picturesque destination ideal for beach lovers and romantics. With its stunning views, outdoor activities, and serene environment, it's perfect for picnics, boating, and sunset strolls along the shore.
  • Veterans Memorial Park: Situated 4 miles from Southern Illinois, this memorial park provides a contemplative space to honor those who served. With its cultural significance and beautiful landscaping, it's an excellent spot for reflection and appreciation of local history.

Best time to go to Southern Illinois

The best time to visit Southern Illinois is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly cloudy with light rain.

Tips to save on your trip to Southern Illinois

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Southern Illinois.
  • Consider traveling during the off-peak season (typically January to February and November) for more affordable package holidays to Southern Illinois.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.