A forested valley with autumn foliage, a rocky cliff, and a sunset.
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Southern Illinois Vacations from $321

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Southern Illinois Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Sep 24 - Sep 28

    Residence Inn by Marriott St Louis Downtown + Flight

    Midtown
    4 nights
    3.0 star property
    7.8/10 - Good (1,002 reviews)
    "Check in tooks hours and went beyond 4pm making ua late for tickets we had, room smelled of old cigarettes, getting help with parking tickets was impossible and overall just a disappointment for a Marriott location."
    Reviewed July 31, 2026
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    Save 100% on your flight
    $584
    $376
    per traveler
    found 2 days ago
    Residence Inn by Marriott St Louis Downtown
  • Sep 6 - Sep 12

    The Wildwood Hotel + Flight

    Wildwood
    6 nights
    3.5 star property
    9.2/10 - Wonderful (1,678 reviews)
    "The breakfast was really good."
    Reviewed August 5, 2026
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    $875
    $455
    per traveler
    found 2 days ago
    The Wildwood Hotel
  • Sep 6 - Sep 12

    Remodeled and Inviting Free EV + Flight

    Fenton
    6 nights
    2.0 star property
    10/10 - Exceptional (1 review)
    "The property was excellent, and the home was very warm and welcoming."
    Reviewed June 25, 2026
    Roundtrip Atlanta (ATL) - St. Louis (STL)
    ATL - STLNonstop STL - ATLNonstop
    Save 100% on your flight
    $1,093
    $642
    per traveler
    found 2 days ago
    Remodeled and Inviting Free EV
  • Sep 10 - Sep 16

    Lodge Of Four Seasons Golf Resort, Marina & Spa + Flight

    Lake Ozark
    6 nights
    4.0 star property
    7.4/10 - Good (1,276 reviews)
    Roundtrip Dallas (DFW) - St. Louis (STL)
    DAL - STLNonstop STL - DFW1 stop
    Save 100% on your flight
    $810
    $538
    per traveler
    found 1 day ago
    Lodge Of Four Seasons Golf Resort, Marina & Spa
  • Sep 10 - Sep 16

    Alhonna Resort LLC + Flight

    Lake Ozark
    6 nights
    3.0 star property
    8.8/10 - Excellent (328 reviews)
    "I rate this resort a 10/10!!! My family loved the live band, the food and drinks were great! The lake was gorgeous! The property was well kept. My kids enjoyed the pools. The housekeeping staff was amazing! The front desk clerks were very nice! My family and I just really had a blast!!!"
    Reviewed August 3, 2026
    Roundtrip Dallas (DFW) - St. Louis (STL)
    DAL - STLNonstop STL - DFW1 stop
    Save 100% on your flight
    $1,006
    $710
    per traveler
    found 1 day ago
    Alhonna Resort LLC

Discover the most popular places to visit in Southern Illinois

Southern Illinois Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book with confidence

Things to do near Southern Illinois

Southern Illinois offers a perfect blend of outdoor adventures and romantic escapes. Visitors can enjoy thrilling ziplines, scenic wine tastings, and extensive hiking trails that showcase the area's natural beauty. With its charming campgrounds and recreational areas, Southern Illinois is ideal for those seeking both excitement and relaxation in a picturesque setting.

Shopping

King City Square Shopping Center, located 5 miles from Southern Illinois, offers a vibrant shopping experience with a mix of entertainment and family-friendly activities. Explore various stores for unique gifts and souvenirs that capture the essence of the region.

Recreation

Experience the vibrant culture at the Benton Civic Center, where entertainment meets romance. Enjoy the serene wellness vibes of Lincoln Park, perfect for relaxation, or visit Waltonville Public Use Area for a peaceful retreat in nature, fostering rejuvenation and tranquility just a short drive away.

Adventure

The I-57 Drag Strip offers thrilling motor racing experiences, located 23 miles from Southern Illinois. Feel the adrenaline rush as cars zoom past, surrounded by a vibrant atmosphere filled with sports enthusiasts. It's an exhilarating spot for anyone looking to embrace high-speed excitement.

Nightlife

Southern Illinois boasts a vibrant nightlife with unique bars and live music venues. Check out the Hangar 9 in Carbondale for great live performances and craft brews. For a relaxed vibe, visit Pheasant Hollow Winery to enjoy local wines and scenic views while unwinding with friends.

Find the best attractions near Southern Illinois

Southern Illinois is perfect for outdoor enthusiasts and those seeking romantic getaways, offering stunning scenery and adventure. Explore its beautiful lakes, national and state parks, and modern colleges and universities. The area's attractions cater to travelers looking for unforgettable outdoor experiences amidst breathtaking landscapes.

  • Jefferson County Fairgrounds: Located 3 miles from Southern Illinois, the Jefferson County Fairgrounds offers a lively atmosphere perfect for family outings. Experience local culture through seasonal fairs, exhibitions, and events, with plenty of outdoor space for relaxing and enjoying the festivities.
  • Rend Lake: A scenic 13 miles from Southern Illinois, Rend Lake is a picturesque destination ideal for beach lovers and romantics. With its stunning views, outdoor activities, and serene environment, it's perfect for picnics, boating, and sunset strolls along the shore.
  • Veterans Memorial Park: Situated 4 miles from Southern Illinois, this memorial park provides a contemplative space to honor those who served. With its cultural significance and beautiful landscaping, it's an excellent spot for reflection and appreciation of local history.

Best time to go to Southern Illinois

The best time to visit Southern Illinois is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly cloudy with light rain.

Tips to save on your trip to Southern Illinois

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Southern Illinois.
  • Consider traveling during the off-peak season (typically January to February and November) for more affordable package holidays to Southern Illinois.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.